2016

LYVE1 marks the divergence of yolk sac definitive hemogenic endothelium from the primitive erythroid lineage.

Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HKA. Cell Reports 2016 Nov 22; **17(9):2286-2298. doi: 10.1016/j.celrep.2016.10.080. https://pubmed.ncbi.nlm.nih.gov/27880904/

Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros.

Ng ES, Azzola L, Vlahos K Hirst C, Jokubaitis VJ, Yu QC, Bruveris FF, Calvanese V, Phipson B, Maksimovic J, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock D, Nilsson SK, Saffery R, Oshlack A, Mikkola HKA, Stanley EG, and Elefanty AG. Nature Biotechnology 2016 Nov;**34(11):1168-1179. doi: 10.1038/nbt.3702. Epub 2016 Oct 17. https://pubmed.ncbi.nlm.nih.gov/27748754/

MEF2C Protects Bone Marrow B Lymphoid Progenitors during Stress Hematopoiesis.

Wang W, Org T, Montel-Hagen A, Pioli P, Israely E, Duan D, Malkin D, Flach J, Schiestl R.H, Mikkola HKA. Nat Commun. 2016 Aug 10;**7:12376. doi: 10.1038/ncomms12376. PMID: 27507714 https://pubmed.ncbi.nlm.nih.gov/27507714/

Critical requirement of VEGF-C in transition to fetal erythropoiesis.

Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K. Blood. 2016 Jun 24. pii: blood-2015-12-687970. [Epub ahead of print] https://pubmed.ncbi.nlm.nih.gov/27343251/

Medial HOXA genes demarcate haematopoietic stem cell fate during human development.

Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. Nat Cell Biol. 2016 Jun;**18(6):595-606. doi: 10.1038/ncb3354. Epub 2016 May 16. https://pubmed.ncbi.nlm.nih.gov/27183470/

Tracking HSC Origin: From Bench to Placenta.

Calvanese V, Mikkola HK. Dev Cell. 2016 Mar 7;**36(5):479-80. doi: 10.1016/j.devcel.2016.02.022. https://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30077-6