Publications

Featured Publications

Developmentally regulated long and short isoforms of MLLT3 balance human hematopoietic stem cell fate decisions.

Vavilina A, Calvanese V, Gu Y, Ma F, Quinones Valdez G, Fares I, Colombo G, Aguade Gorgorio J, Capellera-Garcia S, Nadel B, Wang Y, Nance K, Andrews A, Goodridge H, Seet C, Crooks G, Pellegrini M, Xiao G, Schenke-Layland K, Mikkola HKA. In revision

• 2024

  ---

  MYCT1 controls environmental sensing in human haematopoietic stem cells

  Júlia Aguadé-Gorgorió, Yasaman Jami-Alahmadi, Vincenzo Calvanese, Maya Kardouh, Iman Fares, Haley Johnson, Valerie Rezek, Feiyang Ma, Mattias Magnusson, Yanling Wang, Juliana E. Shin, Karina J. Nance, Helen S. Goodridge, Simone Liebscher, Katja Schenke-Layland, Gay M. Crooks, James A. Wohlschlege & Hanna K. A. Mikkola. Nature (2024): 1-9. https://doi.org/10.1038/s41586-024-07478-x

  Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells

  Elizabeth S. Ng, Gulcan Sarila, Jacky Y. Li, Hasindu S. Edirisinghe, Ritika Saxena, Shicheng Sun, Freya F. Bruveris, Tanya Labonne, Nerida Sleebs, Alexander Maytum, Raymond Y. Yow, Chantelle Inguanti, Ali Motazedian, Vincenzo Calvanese, Sandra Capellera-Garcia, Feiyang Ma, Hieu T. Nim, Mirana Ramialison, Constanze Bonifer, Hanna K. A. Mikkola, Edouard G. Stanley & Andrew G. Elefanty Nature BioTechnology (2024): 1-14.

  https://doi.org/10.1038/s41587-024-02360-7

• 2023

  ---

  The Genesis of Human Hematopoietic Stem Cells.

  Calvanese V and Mikkola HKA. Invited review, Blood 2023, 142 (6): 519–532. 2023. https://doi.org/10.1182/blood.2022017934

• 2022

  ---

  Decoding human hematopoietic stem cell self-renewal.

  Fares I, Calvanese V, Mikkola HKA. Curr Stem Cell Rep (April 18, 2022). Invited review https://doi.org/10.1007/s40778-022-00209-w

  Mapping human haematopoietic stem cells from haemogenic endothelium to birth.

  Calvanese V*, Capellera-Garcia S*, Ma F*, Fares I, Liebscher S, Ng E, Ekstrand S, Aguadé-Gorgorió J, Vavilina A, Lefaudeux D, Nadel B, Li JY, Wang Y, Lee LK, Ardehali R, Iruela-Arispe L, Pellegrini M, Stanely E, Elefanty A, Schenke-Layland K, Mikkola HKA. Nature, 2022 Apr; 604(7906):534-540. doi: 10.1038/s41586-022-04571-x. Epub 2022 Apr 13.PMID: 35418685. https://pubmed.ncbi.nlm.nih.gov/35418685/

  Yolk sac steps up to the plate.

  Mikkola HKA.J Exp Med. 2022 Mar 7; 219(3):e20212315. doi: 10.1084/jem.20212315. Epub 2022 Feb 24.PMID: 35201267. Invited preview. https://pubmed.ncbi.nlm.nih.gov/35201267/

• 2020

  ---

  Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration.

  Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K. Advanced Science. 2020 Dec 21 (4):2002500. doi: 10.1002/advs.202002500.eCollection 2021 Feb https://pubmed.ncbi.nlm.nih.gov/33643791/

  VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche.

  Fang S, Chen S, Nurmi H, Leppänen V-M, Jeltsch M, Scadden D, Silberstein L, Mikkola HKA*, Alitalo K*. Blood, Blood. 2020 Oct 15 (16):1871-1883. Doi10.1182/blood.2020005699.PMID: 32842144 *co-corresponding authors https://pubmed.ncbi.nlm.nih.gov/32842144/

• 2019

  ---

  MLLT3 governs human hematopoietic stem cell self-renewal and engraftment.

  Calvanese V*, Nguyen AT, Bolan T, Vavilina A, Su T, Lee l, Wang Y, Lay FD, Magnusson M, Crooks GM, Kurdistani SK, Mikkola HKA*. Nature 2019. Dec (7786):281-286. Epub 2019 Nov 27. *co-corresponding authors https://pubmed.ncbi.nlm.nih.gov/31776511/

• 2018

  ---

  Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes.

  Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. Nat Commun. 2018 Sep 7 (1):3634. doi: 10.1038/s41467-018-05573-y PMID:30194383 https://www.ncbi.nlm.nih.gov/pubmed/30194383/

  Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells.

  Grace CS, Mikkola HKA, Dou DR, Calvanese V, Ronn RE, Purton LE. Exp Hematol. 2018 Jul 4. pii: S0301-472X(18)30620-9. doi: 10.1016/j.exphem.2018.06.287. [Epub ahead of print] Review. https://www.ncbi.nlm.nih.gov/pubmed/29981365/

  Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.

  Park S, Ranjbarvazirj S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Mikkola HKA, Lusis AJ, Ardehali R. Circulation. 2018 Jun 27. pii: CIRCULATIONA.118.035420. doi: 10.1161/CIRCULATIONAHA.118.035420. [Epub] https://pubmed.ncbi.nlm.nih.gov/29950403/

  Analysis of cardiomyocyte clonal expansion during mouse heart development and injury.

  Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. Nat Commun. 2018 Feb 21 (1):754. doi: 10.1038/s41467-018-02891-z. https://pubmed.ncbi.nlm.nih.gov/29467410/

• 2017

  ---

  Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.

  Komorowska K, Doyle A, Wahlestedt M, Subramaniam A, Debnath S, Chen J, Soneji S, Van Handel B, Mikkola HKA, Miharada K, Bryder D, Larsson J, Magnusson M. Cell Reports. 2017 Dec 19 (12):3514-3523. doi: 10.1016/j.celrep.2017.11.084. https://pubmed.ncbi.nlm.nih.gov/29262330/

• 2016

  ---

  LYVE1 marks the divergence of yolk sac definitive hemogenic endothelium from the primitive erythroid lineage.

  Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HKA. Cell Reports 2016 Nov 22; **17(9):2286-2298. doi: 10.1016/j.celrep.2016.10.080. https://pubmed.ncbi.nlm.nih.gov/27880904/

  Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros.

  Ng ES, Azzola L, Vlahos K Hirst C, Jokubaitis VJ, Yu QC, Bruveris FF, Calvanese V, Phipson B, Maksimovic J, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock D, Nilsson SK, Saffery R, Oshlack A, Mikkola HKA, Stanley EG, and Elefanty AG. Nature Biotechnology 2016 Nov;**34(11):1168-1179. doi: 10.1038/nbt.3702. Epub 2016 Oct 17. https://pubmed.ncbi.nlm.nih.gov/27748754/

  MEF2C Protects Bone Marrow B Lymphoid Progenitors during Stress Hematopoiesis.

  Wang W, Org T, Montel-Hagen A, Pioli P, Israely E, Duan D, Malkin D, Flach J, Schiestl R.H, Mikkola HKA. Nat Commun. 2016 Aug 10;**7:12376. doi: 10.1038/ncomms12376. PMID: 27507714 https://pubmed.ncbi.nlm.nih.gov/27507714/

  Critical requirement of VEGF-C in transition to fetal erythropoiesis.

  Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K. Blood. 2016 Jun 24. pii: blood-2015-12-687970. [Epub ahead of print] https://pubmed.ncbi.nlm.nih.gov/27343251/

  Medial HOXA genes demarcate haematopoietic stem cell fate during human development.

  Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. Nat Cell Biol. 2016 Jun;**18(6):595-606. doi: 10.1038/ncb3354. Epub 2016 May 16. https://pubmed.ncbi.nlm.nih.gov/27183470/

  Tracking HSC Origin: From Bench to Placenta.

  Calvanese V, Mikkola HK. Dev Cell. 2016 Mar 7;**36(5):479-80. doi: 10.1016/j.devcel.2016.02.022. https://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30077-6

• 2015

  ---

  GLI2 inhibition abrogates human leukemia stem cell dormancy

  Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH. J Transl Med. 2015 Mar 21;**13:98. doi: 10.1186/s12967-015-0453-9.

  http://www.ncbi.nlm.nih.gov/pubmed/25889765

  Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence

  Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerenyi M, Sasidharan R, Fujiwara Y, Orkin S, Kurdistani SK, Mikkola HKA. EMBO J Epublication ahead of print Jan 2015. 34(6):759-77

  http://www.ncbi.nlm.nih.gov/pubmed/25564442

  Atlas of the Cellular and Molecular Development of Human Hematopoiesis

  Van Handel B, Chhabra A, Mikkola HKA. Hematopoietic Niches, In, Dame, C., Fliedner, T.M., Sola-Visner, M., Yoder, M.C. (Eds.). 2015 Invited book chapter.

  http://www.springer.com/us/book/9783642246777

  GPI-80 Defines Self-renewal Ability in Hematopoietic Stem Cells during Human Development

  Prashad SL, Calvanese V, Yao CY, Kaiser J, Sasidharan R, Crooks, G, Magnusson M, Mikkola HKA. Cell Stem Cell, 2015 Jan 8;**16(1):80-7. doi: 10.1016/j.stem.2014.10.020. Epub 2014 Nov 13. PMID: 25465114

  http://www.ncbi.nlm.nih.gov/pubmed/25465114

• 2014

  ---

  The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis

  Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. Cell Rep. 2014 May 22;**7(4):1239-47. Epub 2014 May 9.

  http://www.ncbi.nlm.nih.gov/pubmed/24813891

  Sex hormone drives blood stem cell reproduction

  Calvanese V, Lee LK, Mikkola HK. EMBO J. 2014 Mar 18;**33(6) PMID:24562387. Invited News and Views

  http://www.ncbi.nlm.nih.gov/pubmed/24562387

  Progesterone Receptor in the Vascular Endothelium Triggers Physiological Uterine Permeability Pre-implantation

  Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML. Cell. 2014 Jan 30;**156(3):549-62. doi: 10.1016/j.cell.2013.12.025. PMID: 24485460

  http://www.ncbi.nlm.nih.gov/pubmed/24485460

• 2013

  ---

  c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface

  Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti K-J, Ardehali R, Jiang M, Mikkola HKA. Dev Cell 2013;**Nov27(4):373-86.

  http://www.ncbi.nlm.nih.gov/pubmed/24286824

  In vivo mapping of Notch pathway activity in normal and stress hematopoiesis

  Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manet J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, and Aifantis I. Cell Stem Cell, 2013 Jun 19. [Epub ahead of print]. 2013 Aug 1;**13(2):256

  http://www.ncbi.nlm.nih.gov/pubmed/23791481

  Selective suppression of endothelial cytokine production by progesterone receptor

  Goddard LM, Ton AN, Org T, Mikkola HK, Iruela-Arispe ML.Vascul Pharmacol. 2013 Jun 6. doi:pii: S1537 1891 (13)00074-8. \10.1016/j.vph.2013.06.001[Epub ahead of print]. Jul-Aug;**59(1-2):36-43.

  http://www.ncbi.nlm.nih.gov/pubmed/23747964

  Hemogenic endocardium contributes to transient definitive hematopoiesis

  Nakano H, Liu X, Arshi A, Nakashima Y, Van Handel Ben, Sasidharan R, Harmon AW, Shin J-H. Schwartz RJ, Conway S, Harvey RP, Pashmforoush M, Mikkola HKA, Nakano A. Nature Communications, 2013;**4:1564. doi: 10.1038/ncomms2569.

  http://www.ncbi.nlm.nih.gov/pubmed/23747964

  Stem Cells in The Placenta

  Rhodes Erikson KE, Chhabra A, Mikkola HKA. In Perinatal Stem Cell, Ed Kyle Cetrulo, 2013.

  http://onlinelibrary.wiley.com/doi/10.1002/9780470480151.fmatter/pdf

  Ex vivo expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised in vivo reconstitution ability

  Magnusson M, Sierra MI. Sasidharan R, Prashad SL, Saarikoski P, Romero M, Van Handel B, Huang A, Li X, Mikkola HKA. PLOS One. 2013;**8(1):e53912. doi: 10.1371/journal.pone.0053912. Epub 2013 Jan 16.

  http://www.ncbi.nlm.nih.gov/pubmed/23342037

  Nipah virus envelope pseudotyped lentiviruses efficiently target ephrinB2+ stem cell populations in vitro and bypass the liver sink when administered in vivo

  Palomeros, K., Vigant, F., Van Handel, B., Pernet, O., Chikere, K., Hong, P., Sherman, S.P., Patterson, M., An, D.S., Lowry, W.E., Mikkola, H.K., Morizono, K., Pyle, A.D., and Lee, B., J Virol. 2013 Feb;**87(4):2094-108. doi: 10.1128/JVI.02032-12.Epub 2012 Nov 28.

  http://www.ncbi.nlm.nih.gov/pubmed/23192877

• 2012

  ---

  Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis

  Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos J.A, Mikkola HKA, Yuan G-C, Orkin SH. Dev Cell 2012 Oct 3. pii: S1534-5807

  http://www.ncbi.nlm.nih.gov/pubmed/23041383

  Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells

  Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, Maclellan WR. PLoS One.2012;**7(10):e45603. doi:10.1371/journal.pone.0045603. Epub 2012 Oct 9

  http://www.ncbi.nlm.nih.gov/pubmed/23056209

  Lymphoid Priming in Human Bone Marrow Begins Prior to CD10 Expression with Up-Regulation of L-selectin

  Kohn LA, Hao Q-L, Sasidharan R, Parekh S, Ge S, Zhu J, Mikkola HKA, Crooks GM. Nature Immunol, Oct;**13(10):963-71, 2012

  http://www.ncbi.nlm.nih.gov/pubmed/22941246

  Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation

  Li J, Patterson M, Mikkola HKA, Lowry W, Kurdistani SK. Plos Genetics, 2012 Aug;**82012.

  http://www.ncbi.nlm.nih.gov/pubmed/22956909

  Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium

  Van Handel B*, Montel-Hagen A*, Sasidharan R, Ferrari R, Boorgeerd K, Nakano H, Org, T, Li X, Zhou J, Pellegrini M, Orkin SH, Nakano A, Kurdistani SK, Evans S, Mikkola HKA. Cell, 2012, Aug 3. 150:590-605

  http://www.ncbi.nlm.nih.gov/pubmed/22863011

  CCN2/Connective Tissue Growth Factor Is Essential for Pericyte Adhesion and Endothelial Basement Membrane Formation during Angiogenesis

  Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM. PLoS One. 2012;**7(2):e30562. Epub 2012 Feb 20.

  http://www.ncbi.nlm.nih.gov/pubmed/22363445

  Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling

  Chhabra A, Lechner A, Acharya A, Ueno M, Van Handel B, Tallquist M, Mikkola HKA. Dev Cell, 2012 Mar 13;**22(3):651-9

  http://www.ncbi.nlm.nih.gov/pubmed/22387002

  The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo

  Hyde BB, Liesa M, Elorza AA, Qiu W, Haigh SE, Richey L, Mikkola HK, Schlaeger TM and Shirihai OS. Cell Death and Differentiation, 2012 Jan 13. doi: 10.1038/cdd.2011.195. [Epub ahead of print]

  http://www.ncbi.nlm.nih.gov/pubmed/22240895

  Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

  Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. J. Clin Invest 2012, 122(1):337-47.

  http://www.ncbi.nlm.nih.gov/pubmed/22156197

  Defining the nature of human pluripotent progeny

  Patterson M, Chan D, Ha I, Case D, Cui Y, Van Handel B, Mikkola HKA, and Lowry W. Cell Research, 2012 Jan;**22(1):178-93

  http://www.ncbi.nlm.nih.gov/pubmed/21844894

• 2011

  ---

  Return to youth with Sox17

  Chhabra, A., and Mikkola, H.K., Genes Dev, 25(15):1557 - 1562 (08/01/2011).

  http://www.ncbi.nlm.nih.gov/pubmed/21828265

  Recapitulation of the Embryonic Cardiovascular Progenitor Niche

  Schenke-Layland K, Nsair, A, van Handel B, Angelis E, Gluck J, Vitteler M, Goldhaber J, Mikkola HKA, Kahn M, and MacLellan, R. Biomaterials, 2011 32:2748-56. Epub 2011 Jan 22

  http://www.ncbi.nlm.nih.gov/pubmed/21257198

• 2010

  ---

  Regulated expression of microRNAs-126/126* inhibit erythropoiesis from human embryonic stem cells

  Huang, X, Gschweng, E, van Handel B, Cheng, D, Mikkola HKA and Witte, O. Blood, 117(7):2157 - 2165 (2011). Epub Dec 2010.

  http://www.ncbi.nlm.nih.gov/pubmed/21163928

  Hematopoietic stem cell development in the placenta

  Gekas C, van Handel B, Chhabra A, Ueno M, and Mikkola HKA. International Journal for Developmental Biology. 2010 54:1089-1098. Invited review

  http://www.ncbi.nlm.nih.gov/pubmed/20711986

  First trimester human placenta is a site for terminal maturation of primitive erythroid cells

  Van Handel B, Prashad S, Hassenzadeh-Kiabi N, Huang A, Atanassova B, Magnusson M, Chen A, Hamalainen E, Mikkola HKA. Blood 2010 Oct 28;**116(17):3321-30. Epub 2010 Jul 13

  http://www.ncbi.nlm.nih.gov/pubmed/20628147

  Placenta as a novel source of hematopoietic stem cells

  Lee L, Ueno M, Van Handel B and Mikkola HKA. Placenta as a novel source of hematopoietic stem cells. Current Opinion in Hematology. 2010 17:313-8.

  http://www.ncbi.nlm.nih.gov/pubmed/20571394

  Targeting leukemia stem cells

  Mikkola HKA, Radu C, Witte ON. Nature Biotechnology. 2010, 3:237-8.

  http://www.ncbi.nlm.nih.gov/pubmed/20212485

• 2009

  ---

  Derivation of Primordial germ cells from Human Embryonic and Induced Pluripotent Stem Cells is significantly improved by co-culture with human fetal gonadal cells

  Park TS, Galic Z, Conway AE, Lindgren A, Van Handel BJ. Magnusson M, Richter L, Teitell MA, Mikkola HKA, Lowry WE, Plath K, and Clark AT. Stem Cells, 2009. 27:783-95

  http://www.ncbi.nlm.nih.gov/pubmed/19350678

  Hematopoietic stem cell development in the placenta

  Rhodes KE and Mikkola HKA. In Perinatal Stem Cells.

  http://onlinelibrary.wiley.com/doi/10.1002/9780470480151.ch12/summary

  DNA methylation is a guardian of stem cell self-renewal and multipotency

  Gereige LM and Mikkola HKA. Nature Genetics, 2009 41:1164-6

  http://www.ncbi.nlm.nih.gov/pubmed/19862008

  MEF2C is a lineage restricted target of SCL/tal1 and regulates megakaryopoiesis and B-cell homeostasis

  Gekas C, Rhodes K, Gereige LM, Helgadottir HB, Ferrari R, Kurdistani SK, Montecino-Rodriquez E, Bassel-Duby RS, Olson EN, Orkin SH, Pellegrini M, Mikkola HKA. Blood, 2009. 113:3461-71 Prepublication online Feb 13th 2009.

  http://www.ncbi.nlm.nih.gov/pubmed/19211936

  ESAM: Adding to the hematopoietic toolbox

  Mikkola H. Blood, 2009 113:2871-2872.

  http://www.bloodjournal.org/content/113/13/2871

• 2008

  ---

  Human Fetal Hemoglobin Expression is Regulated by the Developmental Stage-Specific Repressor BCL11A

  Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HKA, Hirschhorn JN, Cantor AB, Orkin SH. Science, 2008, 322:1839

  http://www.ncbi.nlm.nih.gov/pubmed/19056937

  The ISSCR Junior Investigators Committee: Moving forward together

  Mikkola H and de Haan, G. Cell Stem Cell 3:389-390. Invited committee forum article

  http://www.cell.com/cell-stem-cell/abstract/S1934-5909(08)00479-7

  Highlights from Philadelphia: ISSCR

  De Bruijn M, Mikkola H, Snoeck WH, Keller G. Cell Stem Cell, 2008, 3:389-390. Invited meeting report

  http://www.cell.com/cell-stem-cell/abstract/S1934-5909(08)00413-X

  Isolation and visualization of hematopoietic stem cells in the placenta

  Gekas C, Rhodes KE and Mikkola HKA. Curr Protoc Stem Cell Biol. 2008 Aug;**Chapter 2:Unit 2A.8.1-2A.8.14 Invited protocol article

  http://www.ncbi.nlm.nih.gov/pubmed/18729047

  UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis

  Elorza AA, Hyde BB, Mikkola HK, Collins S, Shirihai OS. J Biol Chem. 2008283:30461-70. Prepublication online Aug 7 2008.

  http://www.ncbi.nlm.nih.gov/pubmed/18687678

  Hematopoietic Stem Cells in Transit - Where’s the Niche?

  Magnusson M and Mikkola HK. Cell Stem Cell 2008, 2:302.

  http://www.ncbi.nlm.nih.gov/pubmed/18397748

  Reprogrammed fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages

  Schenke-Layland K, Rhodes K, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber J, Mikkola HK, Plath K and MacLellan WR. Stem Cells 26:1537-46. 2008. May, 2008 prepublication online.

  http://www.ncbi.nlm.nih.gov/pubmed/18450826

  The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation

  Rhodes KE, Gekas C, Wang Y, Lux C, Francis C, Hamalainen E, Orkin SH, Yoder M, Mikkola HKA. Cell Stem Cell, 2:252-263, 2008

  http://www.ncbi.nlm.nih.gov/pubmed/18371450

• 2007

  ---

  Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells

  Schenke-Layland K, Angelis E, Rhodes K, Hagvall SH, Mikkola HKA and MacLellan WR. Stem Cells, 2007, 25:1529-38. Prepublication online March 2007.

  http://www.ncbi.nlm.nih.gov/pubmed/17363553

  The hematopoietic stem cell and its niche: A comparative view

  Martinez-Agosto J, Mikkola HKA, Hartenstein V, Banerjee U. Genes Dev. 2007;**21:3044-60.

  http://www.ncbi.nlm.nih.gov/pubmed/18056420

• 2006

  ---

  The journey of developing hematopoietic stem cells

  Mikkola HKA and Orkin SH. Development, 2006, 133: 3733-3744.

  http://www.ncbi.nlm.nih.gov/pubmed/16968814

  Transcriptional activators, repressor and epigenetic modifiers controlling hematopoietic stem cell development

  Teitell MA and Mikkola HKA. Pediatric Res, 2006;**59:33R

  http://www.ncbi.nlm.nih.gov/pubmed/16549546

• 2005

  ---

  Placenta as a site for hematopoietic stem cell development

  Mikkola HKA, Gekas C, Orkin SH and Dieterlen-Lievre F. Exp Hematol, 2005, 33:1048-54.

  http://www.ncbi.nlm.nih.gov/pubmed/16140153

  Placenta is a niche for hematopoietic stem cells

  Gekas C, Dieterlen-Lievre F, Orkin SH and Mikkola HKA. Developmental Cell, 2005, 8:365-375. Prepublication online Feb 28, 2005.

  http://www.ncbi.nlm.nih.gov/pubmed/15737932

  Tie2Cre-mediated gene ablation defines the Stem Cell Leukemia gene (SCL/tal1)-dependent window during hematopoietic stem cell development

  Schlaeger TM, Mikkola HKA, Gekas C, Helgadottir HB and Orkin SH. Blood, 2005, 5:3871-3874. Prepublication online Jan 27, 2005.

  http://www.ncbi.nlm.nih.gov/pubmed/15677556

• 2004

  ---

  Gene targeting and transgenic strategies for analysis of hematopoietic development in the mouse

  Mikkola HKA and Orkin SH. In Baron M, editor, Methods on Molecular Medicine, 2004, 826:3-22.

  http://www.ncbi.nlm.nih.gov/pubmed/15492385

  Decoding Hematopoietic Specificity in the Helix-Loop-Helix Domain of the Transcription Factor SCL/Tal-1 Mol Cell Biol

  Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P and Porcher C. 2004;**24:7491-7502

  http://www.ncbi.nlm.nih.gov/pubmed/15314159

• 2003

  ---

  Hematopoietic stem cells retain long term reconstitution activity and multipotency in the absence of the stem cell leukemia (SCL/tal1) gene

  Mikkola HKA, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara, Y and Orkin SH. Nature 2003;**421:547-51.

  http://www.ncbi.nlm.nih.gov/pubmed/12540851

  CD41 expression marks the initiation of definitive hematopoiesis in the mouse embryo

  Mikkola HKA, Fujiwara Y, Traver D, Schlaeger TM and Orkin SH. Blood 2003;**101:508-16.

  http://www.ncbi.nlm.nih.gov/pubmed/12393529

• 2002

  ---

  The search for the hemangioblast

  Mikkola HKA and Orkin SH. J Hematother Stem Cell Res 2002;**11:9-17.

  http://www.ncbi.nlm.nih.gov/pubmed/11847000

• 2001

  ---

  Lentiviral-Mediated Gene Transfer into Hematopoietic Stem Cells

  Woods N-B, Mikkola H, Nilsson E, Olsson K, Trono D and Karlsson S. J Intern Med. 2001;**249:339-43.

  http://www.ncbi.nlm.nih.gov/pubmed/11298854

• 2000

  ---

  Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells

  Mikkola H, Woods NB, Sjogren M, Helgadottir H, Hamaguchi I, Jacobsen SE, Trono D and Karlsson S. J Virol 2000, 74:11911-11918.

  http://www.ncbi.nlm.nih.gov/pubmed/11090191

  Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells

  Woods NB, Fahlman C, Mikkola H, Hamaguchi I, Olsson K, Zufferey R, Jacobsen SE, Trono D and Karlsson S.. Blood 2000; **96:3725-33.

  http://www.ncbi.nlm.nih.gov/pubmed/11090053

  Lentiviral gene expression during ES cell derived hematopoietic development in vitro

  Hamaguchi I, Panagopoulos I, Andersson E, Woods N-B, Fahlman C, Mikkola H, Carlsson L, Zufferey R, Trono D and Karlsson S. J Virol 2000; **74:10778-84.

  http://www.ncbi.nlm.nih.gov/pubmed/11044122

  Structure and Function of Factor XIII

  in Colman, Hirsh, Marder, Clowes, George, editors, Hemostasis and Thrombosis: Basic principles and Clinical Practise 2000, p 233-47 Loewy A, McDonagh J, Mikkola H, Teller D and Yee V.

  Effect of Val 34 Leu polymorphism on the activation of the coagulation factor XIII-A

  Wartiovaara U, Mikkola H, Szoke G, Haramura G, Karpati L, Balogh I, Lassila R, Muszbek L and Palotie A. Thromb Haemost. 2000; **84:595-600.

  http://www.ncbi.nlm.nih.gov/pubmed/11057856

  Val 34 Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia

  Balogh I, Szoke G, Karpati L, Wartiovaara U, Katona E, Komaromi I, Haramura G, Pfliegler G, Mikkola H and Muszbek L. Blood. 2000; **96:2479-86.

  http://www.ncbi.nlm.nih.gov/pubmed/11001900

• 1999

  ---

  Leu factor XIII polymorphism in inflammatory bowel disease

  Heliö T, Wartiovaara U, Halme L, Turunen U-M, Mikkola H, Palotie A, Färkkilä M and Kontula K. Arg506->Gln factor V mutation and Val34->. Scand J Gastroent 1999; **2:170-4.

  http://www.ncbi.nlm.nih.gov/pubmed/10192195

  Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males

  Wartiovaara U, Perola M, Mikkola H, Tötterman K-J, Salonen V, Tikkanen M, Grant P, Vartiainen E, Karhunen P, Peltonen L and Palotie A. Atherosclerosis 1999; **104:295-300.

  http://www.ncbi.nlm.nih.gov/pubmed/10030380

• 1998

  ---

  Peripheral platelets express VEGF and VEGF-C which are released during platelet activation

  Wartiovaara U, Salven P, Mikkola H, Lassila R, Joukov V, Ristimäki A, Orpana A, Heikinheimo M, Joensuu H, Alitalo K and Palotie A. Thromb Haemost 1998; **80:171-5.

  http://www.ncbi.nlm.nih.gov/pubmed/9684805

  Association of a common polymorphism in the factor XIII gene with myocardial infarction

  Kohler H, Stickland M, Ossei-Gerning N, Carter A, Mikkola H and Grant P. Thromb Haemost 1998;**79:8-13.

  http://www.ncbi.nlm.nih.gov/pubmed/9459313

• 1997

  ---

  Transglutaminase 1 mutations in autosomal recessive congenital icthyosis: private and recurrent mutations in an isolated population

  Laiho E, Ignatius J, Mikkola H, Yee VC, Teller DC, Niemi K-M, Saarialho-Kere U, Kere J and Palotie A. Am J Hum Genet 1997;**61:529-538.

  http://www.ncbi.nlm.nih.gov/pubmed/9326318

  Molecular mechanisms of mutations in FXIII deficiency: in vitro expression in COS-cells demonstrates intracellular degradation of the mutant proteins

  Mikkola H, Muszbek L, Hämäläinen E, Haramura G, Jalanko A and Palotie A. Thromb Haemost 1997;**78:1068-74.

  http://www.ncbi.nlm.nih.gov/pubmed/9241733

  Molecular mechanism of a mild phenotype in coagulation factor FXIII deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA

  Mikkola H, Muszbek L, Laiho E, Syrjälä M, Hämäläinen E, Haramura G, Salmi T, Peltonen L and Palotie A. Blood 1997;**88:1279-87.

  http://www.ncbi.nlm.nih.gov/pubmed/9028951

• 1996

  ---

  Novel aspects of blood coagulation factor XIII. Critical reviews in clinical laboratory sciences

  Muszbek L, Adany R and Mikkola H. 1996;**33:357-421.

  http://www.ncbi.nlm.nih.gov/pubmed/8922891

  Gene defects in factor XIII deficiency. Seminars in Thrombosis and Haemostasis

  Mikkola H and Palotie A. 1996;**22:393-8.

  http://www.ncbi.nlm.nih.gov/pubmed/8989822

  Four novel mutations in coagulation factor XIII deficiency: Consequences to expression and structure of the A-subunit

  Mikkola H, Yee VC, Syrjälä M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L and Palotie A. Blood 1996; **87:141-51.

  http://www.ncbi.nlm.nih.gov/pubmed/8547636

• 1994

  ---

  Deficiency in the A-subunit of coagulation factor XIII: Two novel point mutations demonstrate different effects on transcript levels

  Mikkola H, Syrjälä M, Rasi V, Vahtera E, Peltonen L and Palotie A. Blood 1994; **84:517-25.

  http://www.ncbi.nlm.nih.gov/pubmed/8025280